Why choose HFA-134A for MDI gas?

1. What is HFA-134a? Why is this gas now popular in the market as a metered dose inhaler (MDI) propellant?

1) Chemical name of HFA-134a:


Tetrafluoroethane is a liquefied gas and is in liquid form in packaging. At room temperature and its own vapor pressure, or in a gaseous state at room temperature and atmospheric pressure. Tetrafluoroethane liquid is usually colorless and odorless. Tetrafluoroethane gas has a slight ether smell at high concentrations. Tetrafluoroethane is non-corrosive, non-irritating and non-flammable.

2) This gas is now popular in the market as a propellant for metered dose inhalers (MDI) because tetrafluoroethane is environmentally friendly.

Tetrafluoroethane is a chlorofluorocarbon (HFC or HFA) aerosol injector (containing hydrogen, fluorine and carbon), which is different from Freon CFC (containing chlorine, fluorine and carbon). HFA does not contain chlorine in its molecules and contains hydrogen, which reduces the depletion of the ozone layer. Therefore, tetrafluoroethane can replace CFCs in metered dose inhalers (MDI).

2. There are two kinds of 134a gas on the market. How to choose and distinguish them?

Since tetrafluoroethane has the same vapor pressure, it can also replace CFC-12 as a refrigerant.

Based on this characteristic, tetrafluoroethane gases on the market are HFA-134a (pharmaceutical grade) and R134a (industrial grade) respectively.

What is the main difference between HFA-134a (pharmaceutical grade) and R134a (industrial grade)?

The differences are as follows:

1)HFA-134a is used in medical sprays including:

*MDI (metered dose inhaler), also known as medicinal aerosol or asthma spray, is used to treat asthma, COPD (chronic obstructive pulmonary disease) and respiratory infections.

*Nasal spray for allergic rhinitis, ect.

2)R134a is mainly used as refrigerant R134a and fire extinguishing agent.

3.MDI gas evolution history :

CFC 11, CFC 12 and CFC 114 propellants: Traditionally used in medical sprays and are being phased out under the terms of the Montreal Protocol. Introduction of Modern pMDI Due to environmental concerns about CFCs, other propellants were sought for use in pMDIs. Two hydrofluoroalkane (HFAs) were identified as suitable alternatives, namely HFA-134a (tetrafluoroethane) and HFA-227 (heptafluoropropane). Inhalers using HFA rather than CFC propellants were developed, and the first HFA-pMDI (Air-omirTM, 3M Healthcare) was launched in 1994.


CFC propellants have been replaced by hydrofluorocarbon propellants. Concerns about the use of hydrofluorocarbon propellants have however since arisen since these compounds are potent greenhouse gases; propellant released during the use of a single inhaler results in a greenhouse footprint equivalent to greenhouse gases released during a 180 -mile car journey.

To protect the environment, we always follow this development direction and constantly improve equipment and serve customer needs.

Guangzhou Aile Automation Equipment Co., Ltd. is a high-tech production enterprise specializing in R&D, production and sales of aerosol equipment and cosmetic equipment. The R&D and production plant is located in Taihe Town, Baiyun District, Guangzhou with convenient transportation and industrial development. Aile Automation has a strong technical force, sufficient production capacity, and a perfect quality management system. It is dedicated to providing engineering solutions and services for equipment for domestic and foreign customers.

If you are interested in our machines, please feel free to contact us!

AILE cosmetic mixing project

——-Related Links——

1)MDI Metered-dose Inhaler Aerosol Filling Machine (Small Dose)

2)Medicine binary BOV aerosol filling line

3)Automatic aerosol can filling machine spray can machine

4)Rotary Index Turntable Aerosol Machine (speed 20-30 cans/min)

5)4 In 1 Semi Automatic Deodorant Aerosol Machine



Contact us

Whether you have a question about our mechanical equipment, service or anything else our team is ready to answer all your questions.